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In SURMOUNT-4, patients switched from tirzepatide to placebo at Week 36 experienced a 14.0 % weight -regain at week 88 whereas patients continued on tirzepatide experienced a further 5.5 % reduction in weight at week 88 [148]

Compared with conventional GLP-1 receptor agonists, such as liraglutide and semaglutide, tirzepatide has demonstrated superior efficacy in body weight control in several phase III clinical trials, with average weight reductions exceeding 20% in some study populations (15)